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Kisspeptin
Sexual HealthSingleAlso known as: Kisspeptin-10
A neuropeptide that regulates GnRH release from the hypothalamus, studied for puberty initiation, fertility, and HPG-axis support.
Half-life
0.3 h
Common dose
1 – 10 mg
Dosing frequency
Every Other Day
Administration
Subcutaneous
How it works
Kisspeptin binds KISS1R on GnRH neurons, triggering GnRH release. This drives LH/FSH from the pituitary, supporting testicular/ovarian function.
Protocol notes
Clinical protocols vary widely. Subcutaneous research dosing of 1–10 mg every 1–2 days is reported. Often used in HPG-axis restart contexts.
Reported side effects
Limited human safety data. Possible HPG axis disruption with chronic use, headache.