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Sermorelin
PerformanceSingleAlso known as: GRF 1-29
An older GHRH analog and one of the first synthetic peptides used in clinical practice for GH-deficiency evaluation and treatment.
Half-life
0.2 h
Common dose
100 – 300 mcg
Dosing frequency
Daily
Administration
Subcutaneous
How it works
Sermorelin is the 1–29 amino-acid fragment of natural GHRH. It stimulates pituitary somatotrophs to release endogenous GH, preserving feedback regulation unlike exogenous HGH.
Protocol notes
Clinical protocols dose 100–300 mcg subcutaneously before bed nightly. Cycles of 3–6 months are common in anti-aging clinical contexts. Often combined with GHRPs.
Reported side effects
Injection-site reactions, flushing, transient headache, and rare allergic reactions.